Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Overview of Protein Metabolism

Overview of Protein Metabolism

Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...

Protein Folding Quality Check in the RER

Protein Folding Quality Check in the RER

ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...

Chronic Kidney Disease III: Interprofessional Care

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

Factors Affecting Protein-Drug Binding: Patient-Related Factors

Factors Affecting Protein-Drug Binding: Patient-Related Factors

Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Increased <i>S. epidermidis</i> in the airway-gut microbiome of infants with bronchopulmonary dysplasia.

bioRxiv : the preprint server for biology·2026

Same author

Cerebral Autoregulation and Optimal Blood Pressure from Birth to Surgery in Neonates with Critical Congenital Heart Disease.

Pediatric cardiology·2025

Same author

Breast Milk and Necrotizing Enterocolitis in Congenital Heart Disease: A Case-Control Study.

World journal for pediatric & congenital heart surgery·2024

Same author

Respiratory outcomes of neonates born after previable premature rupture of membranes and treated with gentle ventilation.

Journal of perinatology : official journal of the California Perinatal Association·2024

Same author

Clinical research resource support for off-site research coordinators in intensive and specialty care units.

Clinical and translational science·2023

Same author

The AMPA receptor antagonist perampanel suppresses epileptic activity in human focal cortical dysplasia.

Epilepsia open·2021

Search research articles

Related Experiment Video

Updated: Sep 18, 2025

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model

Published on: April 2, 2021

Effects of protein intake on IGF1 and ROP.

Divya Keerthy^1,2, Angela Holuba³, David Bateman¹

¹Morgan Stanley Children's Hospital, Columbia University, New York, NY, USA.

Journal of Neonatal-Perinatal Medicine

|June 23, 2025

Summary

Higher protein in parenteral nutrition for premature infants increased insulin-like growth factor 1. This intervention was linked to a reduced risk of plus disease in retinopathy of prematurity, suggesting a potential benefit for vulnerable newborns.

Keywords:

insulin-like growth factor 1 plus disease protein intake retinopathy of prematurity

More Related Videos

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents

Published on: September 16, 2020

Characterization of a Novel Human Organotypic Retinal Culture Technique

Characterization of a Novel Human Organotypic Retinal Culture Technique

Published on: June 9, 2021

Related Experiment Videos

Last Updated: Sep 18, 2025

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model

Published on: April 2, 2021

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents

Published on: September 16, 2020

Characterization of a Novel Human Organotypic Retinal Culture Technique

Characterization of a Novel Human Organotypic Retinal Culture Technique

Published on: June 9, 2021

Area of Science:

Neonatal nutrition
Pediatric ophthalmology
Endocrinology

Background:

Insulin-like growth factor 1 (IGF-1) plays a crucial role in neural and retinal development.
Optimizing IGF-1 levels may help prevent serious infant morbidities, such as retinopathy of prematurity.
Retinopathy of prematurity (ROP) is a significant concern in very low birth weight infants.

Purpose of the Study:

To investigate the impact of higher protein content in parenteral nutrition on IGF-1 levels in very low birth weight infants.
To determine the association between enhanced protein intake, IGF-1, and the incidence of retinopathy of prematurity.

Main Methods:

Post-hoc analysis of a prospective, double-blind, randomized controlled trial involving preterm infants (<1250g).
Infants were randomized to receive either high protein (4g/kg/d) or conventional protein (3g/kg/d) parenteral nutrition.
Weekly IGF-1 measurements and regular retinal examinations were conducted.

Main Results:

Infants in the high-protein group showed a significant 21.9% increase in IGF-1 levels (p=0.03).
While overall ROP and severe ROP were not significantly associated with protein intake or IGF-1, the high-protein group had a lower risk of plus disease (OR 0.17, p=0.02).
Infants with plus disease exhibited 25% lower mean IGF-1 levels (p=0.052).

Conclusions:

Higher protein administration in parenteral nutrition is associated with elevated IGF-1 levels in very low birth weight infants.
This nutritional strategy may reduce the risk of developing plus disease, a severe form of ROP.
Further research may elucidate the direct role of IGF-1 in mitigating ROP severity.