Related Experiment Video
Updated: Sep 18, 2025
Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
Published on: April 1, 2022
Lifetime Smoking History and Marijuana Co-use in Patients With Alcohol-related Acute Pancreatitis
Esther A Adeniran1, Sungjin Kim1, Stephen J Pandol1
1Cedars-Sinai Cancer, Cedars-Sinai Medical Center, Los Angeles, CA.
Objectives:
Smoking increases the risk of the first episode of acute pancreatitis (AP), its recurrence, and progression to chronic pancreatitis. Co-use of cigarettes with marijuana may exacerbate health risks, complicating pancreatitis management. Our study aims to investigate the lifetime smoking history and co-use of cigarettes and marijuana in AP patients.
Materials And Methods:
We analyzed smoking history and marijuana use data from a multicenter case-crossover study of alcohol-associated AP patients (n = 145) recruited from June 2020 to June 2024. Lifetime cigarette use was categorized as: history of smoking <1 pack per day (PPD), ≥1 PPD, and nonsmokers. Age-based smoking prevalence was estimated across 2 birth cohorts (1956-1979 and 1980-1998). Risk factors for co-use were also assessed.
Results:
Of the 143 participants enrolled and who completed smoking history interview, 76% were current smokers and 24% were former smokers. Median cumulative pack-years of smoking until enrollment was 20.4 years in ≥1 PPD smokers versus 4.2 years in <1 PPD smokers ( P < 0.001). Peak smoking prevalence was higher in females born in 1980-1998 than females born in 1956-1979 (100% vs 67%), while males showed an opposite trend (61% for 1956-1979 vs 52% for 1980-1998). Of all participants, 20% reported co-use of cigarettes and marijuana, 22% cigarette-only use, and 14% marijuana-only use. Trauma and stressor-related disorders were associated with a lower likelihood of co-use than cigarette-only use (AOR: 0.19, 95% CI: 0.05-0.63, P = 0.010).
Conclusions:
Smoking is highly prevalent in patients with alcohol-associated AP, many of whom also use marijuana. Tailored smoking cessation interventions are needed for AP patients.
Related Concept Videos
01:29Chronic Pancreatitis II: Collaborative Care
Assessment:
01:24Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
01:27Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
01:30Acute Pancreatitis II: Clinical Manifestations and Management
01:26Stress Prevention and Stress Management Techniques IV
01:22Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...