Research on mammary gland hyperplasia compound patents' herbal combination rules based on complex system entropy...

The aim of this study was to investigate the combination rules of herbal compound patents for the treatment of mammary gland hyperplasia (MGH). Herbal compound patents (oral drugs) for the treatment of MGH from the past 31 years were collected, and a database was created. Complex system entropy clustering was used to analyze the prescription rule of herbal compound patents for the treatment of MGH. In total, 765 MGH herbal compound authorized patents, including 136 Chinese herbs, were identified. High-frequency herbs, herbal pairs, and core associations were obtained by complex system entropy clustering. MGH herbal compound patents are known to activate blood circulation, remove stasis, soothe the liver, regulate Qi, clear heat, detoxify, reduce lumps, soften hard mass, dissolve knots, eliminate phlegm, resolve stagnation, expel pus, tonify Qi and blood, nourish Yin-essence, and generate muscle. A combination of 2 or more effective herbs can achieve stronger therapeutic effects (such as activate blood circulation + activate Qi circulation, supplement blood + promote blood circulation, nourish blood + promote Qi circulation, soothe the liver + promote blood circulation, soothe the liver + promote Qi circulation, soothe the liver + soften lumps and dissipate nodules, reduce swelling/dissipate nodules + promote Qi circulation, promote Qi circulation + reduce swelling/discharge pus, promote Qi circulation + tonify spleen/promote water metabolism/clear damp, reduce swelling/disperse nodules/discharge pus + activate blood circulation, etc). The correlation of MGH with herbal compound patents can be effectively analyzed by complex system entropy clustering.