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Call to action-Pediatric MASLD requires immediate attention to curb health crisis

Phillipp Hartmann1,2, Marialena Mouzaki3, Sara Hassan4

  • 1Department of Pediatrics, University of California San Diego, La Jolla, California, USA.

Hepatology (Baltimore, Md.)
|June 23, 2025
PubMed

Insights

Metabolic dysfunction-associated steatotic liver disease (MASLD) in children is a growing public health crisis, increasing mortality risk. Urgent action is needed through awareness, improved care, and clinical trials to combat pediatric MASLD.

Area of Science:

  • Hepatology
  • Public Health
  • Pediatric Gastroenterology

Background:

  • Pediatric metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is rising globally.
  • MASLD is linked to severe childhood comorbidities and a significantly increased risk of early mortality.
  • It is the primary reason for liver transplantation in young adults in the US, yet often underestimated.

Purpose of the Study:

  • To raise awareness of pediatric MASLD as a critical public health issue.
  • To highlight deficiencies in current screening, staging, diagnostic, and therapeutic approaches.
  • To propose actionable steps to address the pediatric MASLD crisis.

Main Methods:

  • Review of current screening and staging practices.
  • Identification of gaps in non-invasive testing and pharmacotherapy.
  • Analysis of the lack of multicenter clinical trials.
  • Proposal of public health strategies and research priorities.

Main Results:

  • Insufficient screening and disease staging practices are prevalent.
  • A lack of accurate non-invasive tests and effective pharmacotherapy exists.
  • Paucity of multicenter clinical trials hinders progress in pediatric MASLD.

Conclusions:

  • Pediatric MASLD is a public health emergency requiring immediate attention.
  • Comprehensive strategies including awareness campaigns, patient empowerment, and multidisciplinary care are essential.
  • Public health policies and targeted clinical trials are urgently needed to control pediatric MASLD.

Keywords:
diagnosticspediatric MASLDpublic healththerapeutics

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