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Synthesis of 1,2-Azaborines and the Preparation of Their Protein Complexes with T4 Lysozyme Mutants
Published on: March 25, 2017
Isolation of azaphilone derivatives from the marine-derived fungus Talaromyces variabilis
Mengxue Wang1, Yun Chen2, Yue Zhang2
1Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, China; Laboratory of Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China.
Abstract:
Three new azaphilone derivatives, namely talavaritones A-C (1-3), together with seven known compounds (4-10) were isolated from the soft coral-derived fungus Talaromyces variabilis. The structures of these compounds were elucidated by comprehensive spectral analyses, DP4+ probability analyses, together with experimental and calculated ECD spectra. Structurally, compound 1 is the first reported example of 1, 2-seco-azaphilone. Moreover, compounds 7-10 exhibited cytotoxic activities against several human cancer cell lines with IC50 values ranging from 4.3 to 29.2 μM.
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