Remote ischaemic preconditioning in cemented hip arthroplasty (the PRINCIPAL study)-randomised controlled trial:...

Area of Science:

• Cardiovascular Medicine
• Orthopedic Surgery
• Nephrology

Background:

• Total hip arthroplasty (THA) is a common procedure for severe osteoarthritis but carries significant surgical risks.
• Patients with comorbidities undergoing THA face elevated risks of myocardial infarction, acute kidney injury, and cognitive dysfunction.
• Remote ischaemic preconditioning (RIPC) is being investigated for its potential cardioprotective effects in high-risk surgical patients.

Purpose of the Study:

• To evaluate the efficacy of remote ischaemic preconditioning (RIPC) in reducing cardiac injury following cemented total hip arthroplasty (THA).
• To assess the impact of RIPC on various secondary outcomes, including arterial stiffness, neural and renal injury biomarkers, systemic inflammation, and oxidative stress.
• To determine the effect of RIPC on major adverse cardiovascular events and all-cause mortality in THA patients.

Main Methods:

• The PRINCIPAL study is a randomized, controlled, parallel-group, blinded trial.
• Participants undergoing cemented THA will be assigned to either an RIPC group or a sham procedure group.
• Primary outcome is peak troponin T concentration; secondary outcomes include biomarkers of cardiovascular, renal, neural, inflammatory, and oxidative stress markers, plus clinical events.

Main Results:

• This section is to be filled once the study is completed and results are available.

Conclusions:

• This section is to be filled once the study is completed and results are available.