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Insidious meningitis induced by brucellosis: a case report

Raghad Mahmoud Alsuliman1, Heba Haj Saleh2, Huda Hossin3

  • 1Faculty of Medicine, Syrian Private University, Damascus, Syria.

Journal of Medical Case Reports
|June 23, 2025
PubMed
Abstract

Insights

Brucellosis is a rare cause of chronic neurological infections. This case highlights the importance of considering Brucella meningitis in patients with persistent, atypical neurological symptoms and re-evaluating diagnostic tests when necessary.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Microbiology

Background:

  • Brucellosis is an uncommon cause of chronic neurological infections.
  • Atypical symptoms can present diagnostic challenges in neuro-infection cases.
  • Prompt diagnosis and treatment are crucial for managing Brucella meningitis.

Purpose of the Study:

  • To report a rare case of Brucella meningitis.
  • To emphasize the diagnostic challenges associated with atypical presentations.
  • To highlight the importance of comprehensive investigation in neuro-infections.

Main Methods:

  • Case report of a 25-year-old female with a 10-month history of progressive headache.
  • Initial misdiagnosis as idiopathic intracranial hypertension due to absent systemic symptoms and an initial negative cerebrospinal fluid test.
  • Comprehensive re-evaluation including Wright test and detection of Brucella antibodies in blood and cerebrospinal fluid.

Main Results:

  • Diagnosis of Brucella meningitis was confirmed through serological and cerebrospinal fluid analysis.
  • The patient presented with atypical, prolonged neurological symptoms.
  • Initial diagnostic workup was insufficient, necessitating re-evaluation.

Conclusions:

  • Brucella meningitis should be considered in the differential diagnosis of chronic neuro-infections.
  • Atypical bacterial infections require broad investigation.
  • Re-evaluation of diagnostic tests is essential when initial results are inconclusive or symptoms persist.
Keywords:
BrucellosisCase reportMeningitis

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