A bilinear control model for tumor growth and chemotherapy

A new bilinear control model using Volterra-like equations is developed to analyze the growth of normal and malignant cells. The model is validated using experimental data on untreated sarcoma in mice. The model equations are modified to account for injection of a chemotherapeutic drug. Two drug scheduling methods are simulated to investigate the effect of the chemotherapeutic agent. The simulation results are in general agreement with clinical observations.