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Updated: Sep 18, 2025

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

17.4K

Α 6-month, multicenter, observational study investigating the treatment of venous thromboembolism in Greece (VICTORIA

Paraskevi Savvari1, Ioannis Skiadas1, Evgenia Mavrokefalou2

  • 1Medical Affairs, Pfizer Hellas S.A, 243 Messoghion Ave, Athens, N. Psychiko, 154 51, Greece.

Thrombosis Journal
|June 23, 2025
PubMed

Insights

Real-world data show that venous thromboembolism (VTE) is often treated with combined oral and parenteral anticoagulants, with direct oral anticoagulants (DOACs) like apixaban being most common. Extended anticoagulation was frequent and adherence rates were high.

Area of Science:

  • Cardiology
  • Hematology
  • Clinical Pharmacy

Background:

  • Real-world data are crucial for guiding clinical practice in venous thromboembolism (VTE) management.
  • Understanding current anticoagulation strategies for VTE is essential.

Purpose of the Study:

  • To determine the types and duration of antithrombotic treatments used in patients with VTE.
  • To investigate anticoagulation dosage, persistence, and adherence in VTE patients.

Main Methods:

  • A prospective, multicenter observational study involving 600 Greek adults with VTE.
  • Data collection included baseline, 3-month, and 6-month follow-up assessments.
  • Analysis focused on treatment patterns, risk factors, and adherence.

Main Results:

  • The most common VTE presentations were pulmonary embolism (PE) and deep vein thrombosis (DVT).
  • Direct oral anticoagulants (DOACs), particularly apixaban, were the predominant oral anticoagulants used, often in combination with parenteral agents.
  • Forty-one percent of patients received extended anticoagulation (>6 months), primarily at standard doses, with high adherence and persistence rates observed.

Conclusions:

  • Current VTE treatment frequently involves a combination of oral and parenteral anticoagulants, with DOACs like apixaban being a leading choice.
  • Extended anticoagulation is common in VTE management, with persistent risk factors influencing its use.
  • High rates of adherence and persistence were noted for both DOAC and non-DOAC anticoagulant therapies.
Abstract

Keywords:
AnticoagulantDeep vein thrombosisDuration of anticoagulationPulmonary embolism

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