Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multimodal optical imaging for the assessment of the teratogenic effects of ethanol on zebrafish development.

Journal of biomedical optics·2026
Same author

Tumor irradiation promotes antigen dressing of dendritic cells to enhance CAR T cell persistence and efficacy in lung metastases.

Nature cancer·2026
Same author

Polystyrene microplastic-induced pathophysiology is driven by disruption of efferocytosis.

Immunity·2026
Same author

Erratum: Assessment of skin fibrosis in a murine model of systemic sclerosis with multifunctional optical coherence tomography (Erratum).

Journal of biomedical optics·2026
Same author

Clinical multimodal Brillouin microscopy-optical coherence elastography system for lens biomechanics.

Journal of biomedical optics·2025
Same author

Non-Invasive Measurement of Elasticity in Glioblastoma Multiforme Validates Decreased TMZ Sensitivity in Astrocyte Co-Culture.

IEEE open journal of engineering in medicine and biology·2025

Related Experiment Video

Updated: Sep 18, 2025

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain
04:17

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain

Published on: March 8, 2024

1.1K

Depth-Resolved Attenuation Coefficient Quantification During Murine Embryonic Brain Development.

Md Mobarak Karim1, Achuth Nair1, Manmohan Singh1

  • 1Department of Biomedical Engineering, University of Houston, Houston, Texas, USA.

Journal of Biophotonics
|June 24, 2025
PubMed
Summary
This summary is machine-generated.

This study measured optical attenuation coefficient (OAC) in developing mouse brains. OAC increases from embryonic day 9.5 to 13.5 due to changes in cell density and extracellular matrix.

Keywords:
attenuation coefficientdevelopmentembryooptical coherence tomography

More Related Videos

Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy
08:49

Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy

Published on: August 1, 2022

3.7K
An Assay for Permeability of the Zebrafish Embryonic Neuroepithelium
06:37

An Assay for Permeability of the Zebrafish Embryonic Neuroepithelium

Published on: October 24, 2012

9.6K

Related Experiment Videos

Last Updated: Sep 18, 2025

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain
04:17

Author Spotlight: Exploring Cell Migration and Gene Roles in the Developing Brain

Published on: March 8, 2024

1.1K
Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy
08:49

Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy

Published on: August 1, 2022

3.7K
An Assay for Permeability of the Zebrafish Embryonic Neuroepithelium
06:37

An Assay for Permeability of the Zebrafish Embryonic Neuroepithelium

Published on: October 24, 2012

9.6K

Area of Science:

  • Developmental biology
  • Biophotonics
  • Neuroscience

Background:

  • Embryonic brain development involves complex morphological and functional changes.
  • Understanding light propagation in developing tissues is crucial for imaging techniques.

Purpose of the Study:

  • To quantify the optical attenuation coefficient (OAC) in the murine embryonic brain.
  • To analyze OAC changes in the forebrain, midbrain, and hindbrain from embryonic day (E)9.5 to E13.5.

Main Methods:

  • Quantification of OAC using optical methods.
  • Focus on key brain regions: forebrain, midbrain, and hindbrain.
  • Developmental time points: E9.5 to E13.5.

Main Results:

  • OAC is lower at earlier embryonic stages (E9.5) due to lower cell density and simpler extracellular matrix (ECM).
  • By E13.5, increased ECM density, vascularization, and cell density lead to higher OAC and reduced light penetration.
  • A consistent increasing trend in OAC was observed across all studied brain regions during development.

Conclusions:

  • Embryonic brain development significantly alters tissue optical properties.
  • Changes in cellular composition, tissue architecture, and ECM density drive the observed increase in OAC.
  • Findings provide insights into light behavior within developing brain tissue.