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Prednisolone elimination in human saliva.
International Journal of Clinical Pharmacology, Therapy, and Toxicology
|September 1, 1985
Summary
Saliva can approximate prednisolone levels, but significant variations exist between individuals. Therefore, salivary measurements are not a reliable substitute for plasma concentrations in biopharmaceutical research.
Area of Science:
- Pharmacokinetics
- Biomedical Science
- Drug Metabolism
Background:
- Prednisolone is a widely used corticosteroid.
- Accurate monitoring of drug concentrations is crucial for biopharmaceutical studies.
- Saliva offers a non-invasive alternative for drug level assessment.
Purpose of the Study:
- To investigate the relationship between salivary and plasma prednisolone concentrations.
- To evaluate the suitability of salivary prednisolone measurements in biopharmaceutical studies.
Main Methods:
- Intravenous administration of prednisolone (16, 32, 48, 64 mg) to 7 healthy subjects.
- Simultaneous collection and analysis of saliva and plasma samples.
- Calculation of the ratio between salivary and plasma prednisolone concentrations.
Main Results:
- An approximate correlation was found between salivary and plasma prednisolone levels.
- Significant inter- and intraindividual variability in the saliva-to-plasma concentration ratio was observed.
- The observed variations limit the precision of salivary estimations.
Conclusions:
- Salivary prednisolone concentrations show a variable relationship with plasma levels.
- Salivary estimations are not a suitable replacement for plasma measurements in biopharmaceutical studies.
- Further research may be needed to explore factors influencing salivary prednisolone levels.