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Unveiling the Vital Role of ACTA2-AS1 in Human Cancers: Molecular Mechanisms and Clinical Applications

Haodong He1,2, Lumei Xiang1,3, Baoqin Pi1,2

  • 1Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443002, China.

Anti-Cancer Agents in Medicinal Chemistry
|June 24, 2025
PubMed
Abstract

Insights

The long non-coding RNA ACTA2-AS1, also known as ZXF1, is implicated in various cancers. This review highlights its role as a potential biomarker and therapeutic target for cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • ACTA2-AS1 (ZXF1) is a long non-coding RNA (lncRNA) located on chromosome 10q23.31.
  • Aberrant ACTA2-AS1 expression is observed in 10 malignant tumors, linked to poor prognosis.
  • It has emerged as a significant factor in cancer research.

Purpose of the Study:

  • To review recent advancements in ACTA2-AS1 research.
  • To examine its expression, functions, and molecular mechanisms in cancer.
  • To evaluate its potential as a diagnostic biomarker and therapeutic target.

Main Methods:

  • Systematic literature search of the PubMed database.
  • Critical analysis of studies on ACTA2-AS1's biological functions in malignant tumors.

Main Results:

  • ACTA2-AS1 influences tumor cell proliferation, apoptosis, cell cycle, migration, invasion, EMT, and drug resistance.
  • It acts as a ceRNA, sponging miRNAs to regulate downstream targets (e.g., SOX7, KLF9) and pathways (e.g., Wnt5a/PKC, mTOR).
  • Demonstrates dual roles in carcinogenesis and tumor suppression.

Conclusions:

  • ACTA2-AS1 exhibits significant potential as a biomarker for cancer diagnosis and prognosis.
  • It represents a promising molecular target for novel cancer therapies.
Keywords:
ACTA2-AS1LncRNAZXF1cancerclinical applications.therapeutic target

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