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Updated: Sep 18, 2025

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
Published on: March 11, 2017
Nine anthropometric indices predict hepatic steatosis and assess liver health in adolescents: a population-based
Ruanchang Chen1,2, Fangzheng Zhou1,2, Jiayao Zhang2,3
1School of Medicine, Shaoxing University, Shaoxing, Zhejiang, China.
Purpose:
The increasing prevalence of obesity among adolescents has resulted in an increase in the incidence of hepatic steatosis; however, the relationship between anthropometric measurements and this condition in youth remains underexplored.
Aims:
To evaluate the effectiveness of nine anthropometric indicators in predicting the risk of hepatic steatosis in adolescents.
Methods:
We assessed several anthropometric indicators, including the abdominal volume index (AVI), body mass index, body roundness index, body adiposity index, conicity index, waist-hip ratio, waist-to-height ratio, and weight-adjusted waist index. Statistical methods such as multivariate logistic regression, smooth curve fitting, and subgroup analysis were employed. Discriminative accuracy was determined using receiver operating characteristic curve analysis, and a tool based on the optimal Youden index was developed.
Results:
All nine indices were significantly correlated with hepatic steatosis in adolescents. AVI demonstrated the strongest predictive ability, with an area under the curve of 0.8454 (95% confidence interval: 0.8221-0.8687, best threshold: 14.9992). Variations in predictive accuracy were observed across racial and ethnic subgroups, highlighting the importance of demographic factors.
Conclusion:
All nine anthropometric indices are associated with hepatic steatosis, with AVI emerging as the most effective tool for assessing liver health in adolescents.
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