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Real-world evidence on biologic use in paediatric asthma: there but not there yet?

Wenjia Chen1

  • 1Saw Swee Hock School of Public Health, National University of Singapore, Singapore.

ERJ Open Research
|June 24, 2025
PubMed

Insights

Persistent unmet needs in severe pediatric asthma require precision medicine for better treatment and reduced steroid toxicity. National registries and health technology assessments are key for cost-effective, sustainable care.

Area of Science:

  • Pediatric Pulmonology
  • Precision Medicine
  • Health Economics

Background:

  • Severe asthma in children presents persistent unmet needs, particularly regarding biologic therapies.
  • Current treatment strategies often involve significant steroid toxicity and suboptimal cost-effectiveness.

Discussion:

  • Precision medicine approaches are crucial for optimizing biologic treatment in severe pediatric asthma.
  • Addressing steroid toxicity and improving cost-effectiveness are critical for sustainable patient care.

Key Insights:

  • Biologics offer potential but require tailored application in pediatric severe asthma.
  • National registries and health technology assessments (HTAs) are vital for evaluating treatment efficacy and economic impact.

Outlook:

  • Future research should focus on developing personalized treatment algorithms for severe asthma in children.
  • Integration of real-world data from registries into HTAs can guide policy and improve patient outcomes.

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