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Updated: Sep 18, 2025

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
Published on: April 21, 2012
Squamous Cell Carcinoma in Chronic Cutaneous Leishmaniasis: Coincidence or Malignant Transformation
Oumaima Bouraqqadi1, Sara Elloudi1, Meryem Zaryouhi2
1Dermatology Department, Hassan II University Hospital, Fez, MAR.
Abstract:
We report the case of a 69-year-old man who developed squamous cell carcinoma (SCC) at the site of a chronic cutaneous leishmaniasis (CL) lesion on the dorsum of his left hand. The lesion had persisted for over three years despite multiple local and systemic treatments. Histopathological examination confirmed the diagnosis of well-differentiated SCC. The patient was lost to follow-up for a year and returned with locally advanced disease, ultimately requiring hand amputation. This case underscores the potential for malignant transformation in chronic leishmaniasis lesions and highlights the need for timely biopsy and long-term monitoring of atypical or non-healing ulcers in endemic regions.
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