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Immediate Implant-Based Breast Reconstruction Using TIGR® Matrix Surgical Mesh: Clinical Outcomes From Our First 100
Giorgio Caddia1,2, Mellie Heinemann2, Marie Osdoit2
1Plastic, Reconstructive, and Aesthetic Surgery Unit, Department of Human Pathology, Policlinico Universitario G. Martino, Messina, ITA.
Cureus
|June 24, 2025
Summary
TIGR® Mesh shows an acceptable safety profile for immediate breast reconstruction, with complication rates comparable to other synthetic meshes and lower than acellular dermal matrices. This cost-effective option is suitable for selected patients.
Area of Science:
- Plastic Surgery
- Breast Reconstruction
- Biomaterials
Background:
- Acellular dermal matrices (ADMs) improve implant-based breast reconstruction but have higher complication rates.
- Synthetic meshes offer a cost-effective alternative to ADMs.
- TIGR® Mesh is a synthetic option for immediate implant-based breast reconstruction.
Purpose of the Study:
- To evaluate the clinical outcomes of immediate implant-based breast reconstruction using TIGR® Mesh.
- To assess complication rates and cosmetic results associated with TIGR® Mesh.
- To compare TIGR® Mesh outcomes with existing literature on ADMs and other synthetic meshes.
Main Methods:
- Retrospective, single-center study of 76 patients (100 breasts) undergoing direct-to-implant (DTI) mastectomy with TIGR® Mesh.
- Complications assessed using Clavien-Dindo classification (grade III or higher).
- Lipofilling used for cosmetic refinement; mastectomy weight analyzed for correlation with complications.
Main Results:
- Mean follow-up of 17.3 months in patients aged 45.5 years.
- Twelve mesh-related grade III complications (10 infections, 2 seromas) out of 21 total events.
- Implant loss in 10 cases; significant inverse correlation between lower mastectomy weight and higher complication risk (p=0.03).
Conclusions:
- TIGR® Mesh demonstrates an acceptable safety profile for breast reconstruction.
- Infection and seroma rates are within the lower range for synthetic meshes and lower than most ADM series.
- Cost-effectiveness and favorable outcomes support TIGR® Mesh use in selected patients, warranting further prospective studies.
