Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

14.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.4K
Autoimmune Disorders01:29

Autoimmune Disorders

683
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
683

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hybrid bioprinting of hierarchical vascular networks at capillary-scale resolution.

Nature chemical engineering·2026
Same author

Running exercise alleviates chronic heart failure by promoting cardiomyocyte autophagic flux through the NEAT1-QKI affecting Beclin1/LC3B mRNA stability.

Biology direct·2026
Same author

Prognostic nutritional index as a predictor of ursodeoxycholic acid response in primary biliary cholangitis: a retrospective study.

BMC gastroenterology·2026
Same author

From probiotic depletion to inflammatory cascade: multi-omics reveals the temporal progression of sleep deprivation-induced gut-liver axis disruption in mice.

Frontiers in microbiology·2026
Same author

4D-printed adaptive hydrogel tissue expanders for ear and breast reconstruction.

Nature biomedical engineering·2026
Same author

Research trends on autoimmune liver diseases and gut microbiota (1989-2025): a bibliometric and visualization analysis based on the web of science core collection database.

Frontiers in immunology·2026

Related Experiment Video

Updated: Sep 18, 2025

Anti-Nuclear Antibody Screening Using HEp-2 Cells
13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

135.4K

Primary Biliary Cholangitis and Seropositive Rheumatoid Arthritis: A Two-Sample Mendelian Randomization Study.

Zongqi Deng1, Wanyang Lei2, Xiao Kuang1

  • 1Department of Clinical Laboratory, Yunnan Molecular Diagnostic Center, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China.

Clinical and Experimental Gastroenterology
|June 24, 2025
PubMed
Summary

Seropositive rheumatoid arthritis (SPRA) increases the risk of primary biliary cholangitis (PBC). Seronegative rheumatoid arthritis (SNRA) does not show a causal link to PBC, guiding future screening protocols.

Keywords:
Mendelian randomizationcausal effectprimary biliary cholangitisrheumatoid arthritis

More Related Videos

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

351
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

377

Related Experiment Videos

Last Updated: Sep 18, 2025

Anti-Nuclear Antibody Screening Using HEp-2 Cells
13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

135.4K
Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

351
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

377

Area of Science:

  • Genetics and Epidemiology
  • Autoimmune Diseases
  • Gastroenterology

Background:

  • Observational studies suggest a link between primary biliary cholangitis (PBC) and rheumatoid arthritis (RA).
  • The causal relationship between RA and PBC remains uncertain.
  • This study investigates the causal links between seropositive RA (SPRA), seronegative RA (SNRA), and PBC.

Purpose of the Study:

  • To evaluate the causal relationship between SPRA and PBC.
  • To determine if SNRA causally influences the risk of PBC.
  • To provide evidence for clinical screening guidelines.

Main Methods:

  • Utilized a Mendelian randomization (MR) framework with genome-wide association study (GWAS) data from a European population.
  • Selected instrumental variables based on genome-wide significance and independence, excluding palindromic, incompatible, and weak instruments.
  • Employed inverse variance weighting (IVW) as the primary analysis, with Bayesian weighted MR, MR-RAPS, MR-Egger, and weighted median as complementary methods. Sensitivity analyses included Cochran's Q test, MR-Egger regression, MR-PRESSO, and leave-one-out analysis.

Main Results:

  • Seropositive rheumatoid arthritis (SPRA) was found to significantly increase the risk of genetic susceptibility to primary biliary cholangitis (PBC) (OR=1.28, 95% CI 1.10-1.4, P=0.001).
  • No significant causal effect of seronegative rheumatoid arthritis (SNRA) on PBC risk was detected.

Conclusions:

  • Seropositive rheumatoid arthritis (SPRA) is a risk factor for developing primary biliary cholangitis (PBC).
  • These findings support the need for increased vigilance and potential screening for PBC in patients diagnosed with SPRA.
  • The study clarifies the distinct roles of SPRA and SNRA in the context of PBC risk.