Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

1.1K
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
1.1K
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

13.6K
G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
13.6K
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

7.5K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
7.5K
Drug Discovery: Overview01:26

Drug Discovery: Overview

8.8K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
8.8K
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

3.6K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
3.6K
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

2.8K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mode-Selective Dual-Level Vibrational Perturbation Theory Assisted by Machine Learning for Rotational and Vibrational Spectra of Benzoic Acid and Aspirin.

The journal of physical chemistry. A·2026
Same author

Reduced Indocyanine Green Clearance Is Associated with Enteral Feeding Intolerance in Septic Patients Without Overt Liver Injury.

Journal of clinical medicine·2026
Same author

IL-22BP attenuates right ventricular remodeling in pulmonary arterial hypertension.

Clinical science (London, England : 1979)·2026
Same author

Oxytocin modulates the neurocomputational mechanisms engaged in learning rank relationships in social networks.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

VPT2 Calculations of Vibrational Energies of CH<sub>3</sub>COOC<sub>6</sub>H<sub>4</sub>COOH Done in Seconds on a Laptop Using a Machine Learned Potential.

The journal of physical chemistry letters·2026
Same author

Risk factors associated with poor sleep quality in maintenance hemodialysis patients: A single-center cross-sectional study.

Medicine·2026

Related Experiment Video

Updated: Sep 18, 2025

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4
06:56

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

Published on: March 10, 2018

13.9K

Progress in structure-based drug development targeting chemokine receptors.

Jin Wang1, Chen Qu2, Peng Xiao3

  • 1Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.

Frontiers in Pharmacology
|June 24, 2025
PubMed
Summary

Chemokine receptors (CCRs) are key regulators of immune cell movement and inflammation. Understanding their structure advances drug design for diseases like cancer and autoimmune disorders.

Keywords:
CCRsGPCRcryo-EMdrug discoverystructure-based drug design (SBDD)

More Related Videos

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

9.0K
Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
10:25

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Published on: September 20, 2019

7.1K

Related Experiment Videos

Last Updated: Sep 18, 2025

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4
06:56

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

Published on: March 10, 2018

13.9K
A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

9.0K
Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
10:25

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Published on: September 20, 2019

7.1K

Area of Science:

  • Immunology and Molecular Biology
  • Structural Biology
  • Pharmacology

Background:

  • Chemokine receptors (CCRs), a vital G protein-coupled receptor (GPCR) subfamily, regulate immune cell migration, inflammation, tissue repair, and tumor microenvironments.
  • Dysfunctional CCRs are linked to infectious diseases, autoimmune disorders, neurodegenerative conditions, and cancer, highlighting their therapeutic potential.

Purpose of the Study:

  • To review current advancements in chemokine receptor (CCR) biology and structural mechanisms.
  • To explore the role of CCRs in various diseases and their potential as therapeutic targets.
  • To provide insights into structure-based drug design (SBDD) for CCRs.

Main Methods:

  • Synthesis of recent findings in CCR biology and disease association.
  • Analysis of high-resolution structural data obtained via cryo-electron microscopy (cryo-EM).
  • Review of computational chemistry approaches for dynamic conformational modeling of CCRs.

Main Results:

  • High-resolution structures and dynamic models of CCRs have been achieved through cryo-EM and computational chemistry.
  • These structural insights provide a strong foundation for structure-based drug design (SBDD).
  • CCR functional dysregulation is implicated in a wide range of pathologies.

Conclusions:

  • Chemokine receptors (CCRs) are crucial for immune responses and implicated in numerous diseases.
  • Advances in structural biology and computational methods facilitate CCR-targeted drug discovery.
  • This review offers a framework for future research in CCR biology and therapeutic development.