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Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
Published on: May 21, 2018
Research progress on microglial pyroptosis and inflammasomes: a comprehensive analysis
Xiaofang Wang1, Zhenyu Li2, Bingxiang Ma3,4
1Hebei University of Chinese Medicine, Shijiazhuang, China.
Background:
Microglial pyroptosis and inflammasome activation play critical roles in neurodegenerative diseases, especially Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). In recent years, substantial attention has been directed toward elucidating their underlying mechanisms, diagnostic approaches, and prognostic implications. This study aimed to analyze the current research landscape, hotspots, and trends in this field.
Methods:
Articles published over the past decade on microglial pyroptosis and inflammasomes were retrieved from the Web of Science Core Collection (WoSCC) database. A comprehensive analysis was conducted, and high-impact articles were examined in depth.
Results:
A total of 958 articles were included. Among these, 664 originated from China, which also had the highest H-index (68), followed by 147 articles from the United States, with an H-index of 48 and the highest centrality (0.68). Southern Medical University (China) was the leading institution in terms of articles (47) and achieved the highest H-index (19). Journal of Neuroinflammation published the most articles (59) in this field. High-impact studies predominantly focused on the roles of microglial pyroptosis and inflammasomes in neurodegenerative diseases, neuroinflammation and therapeutic intervention strategies. Keywords such as "depression," "cell death," "recovery," and "pathogenesis" emerged as research hotspots over the past 3 years.
Conclusion:
Microglial pyroptosis and inflammasome activation have become research hotspots in neurodegenerative disease, with China and the United States leading in article output and research influence in this field. Southern Medical University (China) is the most influential institution, and the Journal of Neuroinflammation is the most prolific journal. Current research hotspots emphasize elucidating the pathological mechanisms of microglial pyroptosis and inflammasome activation in neurodegenerative diseases, especially in AD, PD, and MS, and exploring potential therapeutic strategies such as MCC950, quercetin, MicroRNA-7, and melatonin. Future studies are expected to focus on mechanism elucidation, disease specificity, dynamic regulation, targeted interventions, and clinical translation to enhance treatment outcomes and prognosis for neurological disorders.
Insights
Microglial pyroptosis and inflammasome activation are key in neurodegenerative diseases like Alzheimer's and Parkinson's. Research is rapidly advancing, with China and the US leading studies on mechanisms and potential therapies.
Area of Science:
- Neuroscience
- Immunology
- Pathology
Background:
- Microglial pyroptosis and inflammasome activation are implicated in neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS).
- Understanding the mechanisms, diagnostics, and prognostics of these processes is crucial for developing effective treatments.
Purpose of the Study:
- To analyze the current research landscape, identify key hotspots, and determine emerging trends in the study of microglial pyroptosis and inflammasomes in neurodegenerative diseases.
Main Methods:
- A bibliometric analysis of 958 articles published over the past decade was conducted using the Web of Science Core Collection (WoSCC) database.
- High-impact articles were examined to identify influential institutions, journals, and research themes.
Main Results:
- China (664 articles) and the United States (147 articles) are the leading countries in publications and research influence.
- Southern Medical University (China) and the Journal of Neuroinflammation are the most prolific and influential contributors.
- Recent research hotspots include "depression," "cell death," "recovery," and "pathogenesis," with a focus on therapeutic strategies like MCC950, quercetin, MicroRNA-7, and melatonin.
Conclusions:
- Microglial pyroptosis and inflammasome research is a rapidly growing field, with significant contributions from China and the US.
- Current research focuses on understanding pathological mechanisms and exploring novel therapeutic interventions for neurodegenerative diseases.
- Future directions include mechanism elucidation, disease specificity, dynamic regulation, targeted interventions, and clinical translation for improved patient outcomes.
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