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Longitudinal Evaluation of Mouse Hind Limb Bone Loss After Spinal Cord Injury using Novel, in vivo, Methodology
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Preserved ambulation in a puppy with severe thoracolumbar myelodysplasia

E Donoghue1, M Koo1, N Jeffery1

  • 1Department of Small Animal Clinical Sciences, Texas A&M University, College Station, Texas, USA.

The Journal of Small Animal Practice
|June 24, 2025
PubMed
Abstract

No abstract available in PubMed .

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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

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