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Updated: Sep 18, 2025

Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro

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Published on: February 15, 2022

CMKLR-1 Expression in Human Aorta Is Dominated by Smooth Muscle Cell Positivity.

Hannes Öster^1,2, Trina Chen^1,2,3, Ari Mennander^1,3

¹Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society

|June 24, 2025

Summary

Chemokine-like receptor 1 (CMKLR-1) is found in human aorta smooth muscle cells. Its expression did not differ between aortic dissection and aneurysm cases in this study.

Keywords:

CMKLR-1 aortic aneurysm aortic dilatation chemerin hypertension inflammation

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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

Area of Science:

Vascular Biology
Immunology
G-protein-coupled receptors

Background:

Chemokine-like receptor 1 (CMKLR-1) binds chemerin and influences immune cell chemotaxis.
CMKLR-1 has been implicated in vascular remodeling associated with inflammation.

Purpose of the Study:

To investigate CMKLR-1 expression in human aorta samples.
To determine CMKLR-1 distribution across aortic cell types.
To assess the association of CMKLR-1 expression with aortic dissection and aneurysms.

Main Methods:

Immunohistochemical staining for CMKLR-1 was performed on 62 human aorta samples.
Samples were from patients with aortic dissection (n=27) or aneurysm/dilatation (n=35).
Expression was analyzed in relation to cell types and clinical/histomorphological data.

Main Results:

CMKLR-1 expression was primarily localized to smooth muscle cells (SMCs) in the aortic media.
Limited staining was observed in vasa vasorum; rare in lymphocytes, macrophages, and endothelia.
No significant differences in CMKLR-1 expression were found between dissection and aneurysm groups or with clinical data.

Conclusions:

CMKLR-1 is present in the aortic media, particularly within SMCs.
CMKLR-1 expression levels did not differentiate between aortic dissection and aneurysms in this cohort.
Further research may clarify CMKLR-1's specific role in aortic pathologies.