Related Experiment Video
Updated: Sep 18, 2025

In Vitro Reconstitution of Self-Organizing Protein Patterns on Supported Lipid Bilayers
Published on: July 28, 2018
Self-alignment and anti-self-alignment suppress motility-induced phase separation in active systems
Marco Musacchio1, Alexander P Antonov1, Hartmut Löwen1
1Institut für Theoretische Physik II: Weiche Materie, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, D-40225 Düsseldorf, Germany.
Self- and anti-self-alignment mechanisms in dense active matter significantly alter collective behaviors. Both phenomena suppress motility-induced phase separation (MIPS), leading to flocking or freezing transitions.
Area of Science:
- Physics
- Soft Matter Physics
- Statistical Mechanics
Background:
- Dense active matter systems exhibit complex collective behaviors.
- Motility-induced phase separation (MIPS) describes non-equilibrium coexistence in active matter.
- Self- and anti-self-alignment are key mechanisms influencing particle orientation and motion.
Purpose of the Study:
- To investigate the impact of self-alignment and anti-self-alignment on collective phenomena in dense active matter.
- To understand how these alignment mechanisms affect motility-induced phase separation (MIPS).
Main Methods:
- Theoretical analysis of effective torques influencing particle orientation.
- Study of MIPS in dense active granular systems.
- Application of scaling arguments to interpret results.
Main Results:
- Both self- and anti-self-alignment suppress clustering in MIPS.
- Increasing self-alignment leads to flocking within clusters and a homogeneous flocking phase.
- Anti-self-alignment induces a freezing phenomenon, suppressing MIPS and resulting in a homogeneous phase.
Conclusions:
- Self- and anti-self-alignment mechanisms play a crucial role in governing collective dynamics in dense active matter.
- These findings offer insights into phase separation and emergent behaviors.
- Results are experimentally verifiable in active granular systems.
Related Concept Videos
Cytoskeletal Coordination in Cell Migration
Cell Polarization by Rho Proteins
Actin Polymerization and Cell Motility
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
Anaphase A and B
Plus-end depolymerization releases tubulin heterodimers from the terminal region of the microtubule. As tubulin subunits are lost, the Ndc80 complexes detach...
Forces Acting on Chromosomes
Microtubules and motor proteins exert two types of forces on...
Mechanism of Filopodia Formation
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...

