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Draft genome of Staphylococcus epidermidis clinical isolate OGSA-Sep-145 from an implant-related spinal infection

Vincenzo Pennone1, Matteo Briguglio2, Elena De Vecchi3

  • 1IRCCS Istituto Ortopedico Galeazzi, Cell and Tissue Engineering Laboratory, Milan, Italy.

Microbiology Resource Announcements
|June 24, 2025
PubMed

Insights

This study presents the genome of Staphylococcus epidermidis strain OGSA-Sep-145, isolated from a spinal infection. The findings offer insights into antimicrobial resistance and virulence factors contributing to chronic implant-related infections.

Area of Science:

  • Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Staphylococcus epidermidis is a common skin bacterium.
  • It frequently causes orthopedic implant-related infections.
  • Biofilm formation and immune evasion are key virulence factors.

Purpose of the Study:

  • To present the draft genome sequence of Staphylococcus epidermidis strain OGSA-Sep-145.
  • To identify genetic determinants of antimicrobial resistance and virulence.
  • To understand mechanisms underlying chronic implant-associated infections.

Main Methods:

  • Whole-genome sequencing of Staphylococcus epidermidis strain OGSA-Sep-145.
  • Bioinformatic analysis of the genome.
  • Comparative genomics to identify virulence and resistance genes.

Main Results:

  • The draft genome of strain OGSA-Sep-145 was successfully sequenced.
  • Potential genes associated with biofilm formation were identified.
  • Genes linked to antimicrobial resistance and immune evasion strategies were elucidated.

Conclusions:

  • The genome sequence provides a valuable resource for studying Staphylococcus epidermidis pathogenesis.
  • Understanding these mechanisms can aid in developing strategies against implant-related infections.
  • This research contributes to the knowledge of chronic infectious disease mechanisms.
Keywords:
genome analysisprosthesis infections

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