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Updated: Sep 18, 2025

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
Published on: December 7, 2014
Rho kinase inhibitors: a patent review (2017-2023)
Daniela Rodrigues de Oliveira1,2, Heber Victor Tolomeu1, Carlos Alberto Manssour Fraga1,2
1Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Instituto de Ciências Biomédicas (ICB), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Introduction:
Rho-associated protein kinases (ROCK) play a crucial role in various biological processes, making them a valuable therapeutic target. Recent FDA approvals of ROCK-targeting drugs have brought renewed focus to this area, which this review aims to explore.
Areas Covered:
This review examines patents published from 2017 to 2023, highlighting novel ROCK inhibitors, progress on previously studied compounds, and new therapeutic applications. A thorough literature search was conducted using patent databases and relevant publications.
Expert Opinion:
Fasudil, ripasudil, netarsudil, and belumosudil are the primary ROCK inhibitors approved for human use. Despite some pharmacokinetic challenges, research in this field continues to advance, with significant potential for further clinical development.
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