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Updated: Sep 18, 2025
Bioluminescence Imaging of an Immunocompetent Animal Model for Glioblastoma
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Bioluminescent Imaging of Patient-Derived Brain Tumors in Live Mice
Dillon McKenna1, Chitra Venugopal1, Sheila K Singh2
1Centre for Discovery in Cancer Research, McMaster University, Hamilton, ON, Canada.
Abstract:
Patient-derived tumor xenograft (PDX) models are crucial for understanding brain tumor progression and for pre-clinical evaluation of therapeutic interventions. Luciferase-based bioluminescence imaging offers a non-invasive approach to visualizing and quantifying tumor development across multiple time points. This chapter presents a methodology for employing the IVIS® (in vivo imaging) system to analyze tumor dynamics in luciferase expressing PDX brain tumor models.
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