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EUS-guided ethanol ablation in patients with solid pseudopapillary neoplasm: a four-case series
Yousik Myung1, Kazuo Hara2, Shin Haba1
1Department of Gastroenterology, Aichi Cancer Center, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan.
Clinical Journal of Gastroenterology
|June 24, 2025
Summary
Endoscopic ultrasound-guided ethanol ablation (EUS-EI) shows promise for treating pancreatic solid pseudopapillary neoplasms (SPN) in patients unsuitable for surgery. This minimally invasive technique demonstrated safety and efficacy in a small patient group.
Area of Science:
- Gastroenterology
- Oncology
- Interventional Endoscopy
Background:
- Solid pseudopapillary neoplasm (SPN) is a rare pancreatic tumor with low malignant potential.
- A subset of SPNs (10-15%) can exhibit invasive or metastatic characteristics.
- Surgical resection is the standard treatment, but not all patients are candidates.
Purpose of the Study:
- To evaluate the safety and efficacy of endoscopic ultrasound-guided ethanol ablation (EUS-EI).
- To assess EUS-EI as an alternative treatment for SPN in patients ineligible for surgery.
Main Methods:
- Four patients with SPN who declined or were ineligible for surgery were treated with EUS-EI.
- Technical success, clinical outcomes, and adverse events were systematically assessed.
Main Results:
- Technical success was achieved in all four patients (100%).
- Clinical success, defined as complete ablation or significant tumor reduction, was observed in three patients (75%).
- No major adverse events or tumor recurrence were reported during the follow-up period.
Conclusions:
- EUS-EI appears to be a safe and effective therapeutic option for managing SPN.
- This endoscopic approach offers a viable alternative for patients with SPN who are not candidates for surgical intervention.
