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Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
Classification of Breast Cancer Microarray Data and Identification of Responsible Genes Using Rough Set Theory
1Department of Electronics and Communication Engineering, Jalpaiguri Government Engineering College, Jalpaiguri, India.
Abstract:
A critical challenge of the post-genomic era is to find out the cancer causing genes that induce changes in gene expression profiles of the microarray dataset. Suitable analysis of microarray dataset can unlock the mystery of the origin of many dreaded disease like cancer which can subsequently be investigated for its rectification, resulting into search for drug design. In this work, Rough Set Theory (RST)-based techniques have been applied for the same purpose. Rough Set has been used to classify the microarray data and isolate responsible genes from classification-based microarray dataset. This extracted information are essential for their ability to describe complex stochastic processes like gene transcription, classification of biological sequencing, and intuitive model for finding causal influence. The experiment is carried out on the microarray dataset of breast cancer (GSE-38867) which has four stages of cancer, i.e., normal, ductal, invasive, and metastatic. RST shows very promising results in terms of predicting different stages of cancer.
Insights
This study uses Rough Set Theory (RST) to analyze gene expression data from breast cancer microarrays. RST effectively identifies cancer-causing genes and predicts different cancer stages from gene expression profiles.
Area of Science:
- Bioinformatics
- Genomics
- Computational Biology
Background:
- Identifying cancer-causing genes is crucial in the post-genomic era.
- Microarray datasets offer insights into gene expression changes related to cancer.
- Understanding cancer origins can guide drug design and treatment strategies.
Purpose of the Study:
- To apply Rough Set Theory (RST) for analyzing microarray data.
- To classify microarray data and isolate genes responsible for cancer.
- To investigate the potential of RST in understanding cancer development.
Main Methods:
- Utilized Rough Set Theory (RST) based techniques.
- Applied RST for classification of microarray data.
- Focused on gene expression profiles from a breast cancer dataset (GSE-38867).
Main Results:
- RST successfully classified microarray data.
- Identified key genes associated with different cancer stages.
- Demonstrated promising predictive capabilities for cancer stages.
Conclusions:
- RST is a valuable tool for analyzing complex biological data like microarrays.
- RST facilitates the identification of cancer-related genes and prediction of disease progression.
- The findings support RST's utility in cancer research and potential for drug discovery.
