Immunological effect of cycloheximide in mice

We evaluated the effects of cycloheximide on two immune responses in the mouse. The data obtained in this series of experiments showed enhancement of the direct splenic plaque-forming cell response to sheep red blood cells when the drug was administered at doses of 25 and 50 mg/kg i.p. and of the delayed type hypersensitivity reaction to oxazolone when cycloheximide was injected at doses of 10, 25 and 50 mg/kg i.p. Depression of these responses was observed when the dose of drug injected was 75 or 100 mg/kg i.p. At a dose of 5 mg/kg cycloheximide had no effect on these immune responses.