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The Silent Masquerader: Paroxysmal Nocturnal Hemoglobinuria Revealed

Akshay S Hegde1, Avinash H Rajanna2, S T Kavya3

  • 1Post Graduate, Department of General Medicine, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India, Corresponding Author.

The Journal of the Association of Physicians of India
|June 24, 2025
PubMed

Paroxysmal nocturnal hemoglobinuria (PNH), a rare acquired hematological disease, is identified by chronic hemolysis due to uncontrolled complement activation. We are reporting three cases-case 1: a 30-year-old male with hemolytic anemia and recurrent hospitalizations for blood transfusion who came with easy fatigability, breathlessness, jaundice, and pedal edema. Case 2: a 28-year-old female with hemolytic anemia who presented with fever, loose stools, reduced urine output, and hematuria. Case 3: a 37-year-old male presented with easy fatigability and jaundice and had splenomegaly on examination. All three cases were positive for different PNH clones on flow cytometry.

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