Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

7.3K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
7.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Within-subject alterations in CSF and blood flow dynamics following rhythm-control intervention in atrial fibrillation: An exploratory multimodal MRI study.

NeuroImage. Clinical·2026
Same author

Reflections from Mathias Bähr, PhD, Editor-in-Chief for Molecular and Cellular Neuroscience, 2017-2026.

Molecular and cellular neurosciences·2026
Same author

[Advances in Anti-Dementia Therapies in Older Adults].

Deutsche medizinische Wochenschrift (1946)·2026
Same author

Real-time phase-contrast MRI can be used to quantify cerebrovascular reserve capacity - a comparative study to neurovascular ultrasound in healthy subjects.

Neuroimage. Reports·2026
Same author

One-Stop Management Improves Outcome for Large Vessel Occlusion Stroke.

Stroke (Hoboken, N.J.)·2026
Same author

Detection and characterization of physiological network interactions in pulsatile motion of cranial blood vessels using real-time MRI.

Frontiers in network physiology·2026

Related Experiment Video

Updated: Sep 18, 2025

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

1.8K

Atrial fibrillation reduces CSF flow dynamics. A multimodal MRI study.

Sabine Hofer1, Marlena Schnieder2, Leonie Polster1

  • 1Department of Neurology, University Medical Center Göttingen, Germany.

Neuroimage
|June 24, 2025
PubMed
Summary

Atrial fibrillation (AF) disrupts the brain's waste clearance system by reducing and altering cerebrospinal fluid (CSF) flow rhythm. This suggests impaired glymphatic system function in AF patients.

Keywords:
AnatomyAtrial fibrillationBrainCognitive declineFlow dynamicsGlymphatic systemMRIReal-time MRI

More Related Videos

Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders
05:23

Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders

Published on: May 31, 2024

651
A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
09:36

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

100

Related Experiment Videos

Last Updated: Sep 18, 2025

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

1.8K
Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders
05:23

Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders

Published on: May 31, 2024

651
A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
09:36

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

100

Area of Science:

  • Neuroscience
  • Cardiology
  • Medical Imaging

Background:

  • Atrial fibrillation (AF) is linked to cognitive decline, but underlying mechanisms remain unclear.
  • The brain's glymphatic system (GS) clears waste via cerebrospinal fluid (CSF) flow, requiring synchrony with blood flow.
  • Investigating GS function in AF is crucial for understanding cognitive impairment.

Purpose of the Study:

  • To examine glymphatic system function in patients with atrial fibrillation.
  • To assess cerebrospinal fluid (CSF) dynamics in relation to blood flow in AF.
  • To utilize a fast multimodal magnetic resonance imaging (MRI) protocol.

Main Methods:

  • 13 healthy volunteers and 13 AF patients underwent 3T MRI.
  • Real-time phase-contrast flow MRI captured CSF and blood flow.
  • Advanced diffusion MRI techniques assessed fluid motion and whole-brain CSF dynamics.

Main Results:

  • AF patients exhibited reduced and aperiodic CSF flow compared to controls.
  • Lower CSF flow volume and less periodic flow patterns were observed in AF patients.
  • No significant differences in brain volume, ventricular size, white matter integrity, or perivascular fluid flow were found.

Conclusions:

  • Atrial fibrillation alters CSF dynamics and disrupts flow rhythmicity.
  • These changes likely impair glymphatic system function.
  • Further research is needed to elucidate the link between AF, GS dysfunction, and cognitive impairment.