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Helicobacter pylori infection induces STAT3/MYBL2/NF-κB axis to promote gastric cancer progression

  • 0Research Center of Basic Medicine, Central Hospital Affiliated to Shandong First Medical University, Jinan 250013, PR China; Department of Medical Laboratory, Shandong Second Medical University, Weifang 261053, PR China.
Tissue & Cell +

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June 24, 2025

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June 24, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Helicobacter pylori infection increases MYBL2 expression, promoting gastric cancer (GC) cell growth and migration. Targeting this pathway may offer new strategies for treating H. pylori-associated GC.

Area Of Science

  • Oncology
  • Gastroenterology
  • Molecular Biology

Background

  • Helicobacter pylori (H. pylori) infection is a major risk factor for gastric cancer (GC).
  • The role of MYBL2 in H. pylori-induced GC progression remains under-investigated.
  • MYBL2 is implicated in the oncogenesis of various cancers.

Purpose Of The Study

  • To investigate the expression and clinical significance of MYBL2 in GC.
  • To elucidate the role of MYBL2 in H. pylori-mediated GC development.
  • To identify the molecular mechanisms linking H. pylori infection, MYBL2, and GC progression.

Main Methods

  • Analyzing MYBL2 expression in GC tissues and cell lines.
  • Inducing H. pylori infection in vitro and in vivo models.
  • Assessing the impact of MYBL2 modulation on GC cell proliferation, migration, and tumor growth in xenograft models.
  • Investigating the upstream and downstream signaling pathways involving STAT3, MYBL2, and NF-κB.

Main Results

  • H. pylori infection significantly upregulated MYBL2 expression in GC.
  • Downregulation of MYBL2 suppressed H. pylori-induced GC cell proliferation and migration.
  • MYBL2 promoted tumor growth in vivo.
  • H. pylori infection activated STAT3, leading to increased MYBL2 expression.
  • MYBL2 was identified as an upstream regulator of NF-κB activation in GC cells.

Conclusions

  • The H. pylori/STAT3/MYBL2/NF-κB signaling axis is crucial for regulating H. pylori-induced GC.
  • MYBL2 plays a significant role in the progression of gastric cancer associated with H. pylori infection.
  • Targeting the MYBL2 pathway presents a potential therapeutic strategy for H. pylori-related GC.

Keywords:

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