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Published on: August 12, 2018
Deep brain stimulation for refractory epilepsy: A meta-analysis of stimulation parameters
Pooya Vahedi1, Shahab Lotfinia2, Alireza Zali3
1School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background:
Epilepsy affects approximately 50 million people worldwide, with around 30 % not responding to antiepileptic drugs. Neuromodulation therapies, such as deep brain stimulation (DBS), are increasingly crucial for managing poorly controlled epilepsy.
Methods:
This study conducted a meta-analysis following PRISMA guidelines, systematically searching PubMed, Scopus, and Web of Science databases for studies on DBS in refractory epilepsy patients. Out of an initial 568 papers screened by title and abstract, 49 studies met the inclusion criteria, involving a total of 682 patients.
Results:
Various DBS interventions were analyzed, targeting regions such as the anterior nucleus of the thalamus, centromedian thalamic nucleus, and hypothalamus, with diverse stimulation parameters, including voltage, frequency, and stimulation type. The analysis revealed that these parameters significantly impacted treatment success, with moderate variability among studies.
Conclusions:
This meta-analysis underscores the importance of tailored DBS parameters to improve outcomes in patients with drug-resistant epilepsy, highlighting DBS as a promising treatment approach.
