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Updated: Sep 18, 2025

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes
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Antidiabetic sitagliptin influences tissue regeneration by affecting progenitor cells

Bárbara Torrecillas-Baena1, Victoria Pulido-Escribano1, José Manuel Quesada-Gómez2

  • 1Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía, Córdoba 14004, Spain.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|June 24, 2025
PubMed
Summary

Sitagliptin, a dipeptidyl peptidase-4 inhibitor (DPP4i), accelerates diabetic wound healing but may impair bone formation by altering serum composition and progenitor cell differentiation.

Keywords:
BoneDPP4 inhibitorsDiabetesEndothelial progenitor cellsMesenchymal stem cellsSitagliptinWound healing

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