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Bioadhesive polymers in transdermal formulations for skin disorders
Sanjeevani R Desai1, Durgacharan A Bhagwat2, Anil Kumar Singh3
1KCT's Krishna College of Pharmacy Karad, India.
Current Opinion in Pharmacology
|June 24, 2025
Summary
Bioadhesive polymers enhance transdermal drug delivery (TDD) for skin disorders by improving drug retention and release. Innovations in materials offer new possibilities for dermatological treatments.
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Dermatology
Background:
- Transdermal drug delivery (TDD) offers advantages like improved patient compliance and sustained release over conventional methods.
- Bioadhesive polymers are essential in TDD for enhancing drug retention and achieving controlled release profiles.
Purpose of the Study:
- To review the applications of bioadhesive polymers in transdermal formulations for skin disorders.
- To explore their adhesion mechanisms, structural modifications, and therapeutic potential.
Main Methods:
- Literature review of bioadhesive polymers in transdermal formulations.
- Analysis of natural (alginate, chitosan) and synthetic (PVA, PVP) polymers.
- Examination of current challenges and recent innovations.
Main Results:
- Natural bioadhesives exhibit anti-inflammatory, antimicrobial, and wound-healing properties.
- Synthetic polymers provide controlled release and mechanical stability.
- Challenges include adhesion failure, moisture sensitivity, and limited macromolecular delivery.
Conclusions:
- Bioadhesive polymers are crucial for effective transdermal drug delivery in dermatology.
- Ongoing innovations like hydrogels and nanofibers address current limitations and expand therapeutic applications.
