Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Cochlea01:13

The Cochlea

46.0K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
46.0K
Echo01:06

Echo

607
The human ear cannot distinguish between two sources of sound if they happen to reach within a specific time interval, typically 0.1 seconds apart. More than this, and they are perceived as separate sources.
Imagine the sound is reflected back to the ears. Assuming that the source is very close to the human, the difference between hearing the two sounds—the emitted sound and the reflected sound—may be more than the minimum time for perceiving distinct sounds. If this is the case,...
607
Auditory Pathway01:15

Auditory Pathway

5.8K
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
5.8K
Hearing01:31

Hearing

53.1K
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
53.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perioperative Code Status Discussions in Surgical Practice: Results from a National Survey Among Swiss Surgeons.

Annals of surgery open : perspectives of surgical history, education, and clinical approaches·2026
Same author

Does Checklist-Guided Shared Decision Making Have a Sustained Effect on Code Status Decisions Among Medical Inpatients? Long-Term Follow Up of the Randomized CLEAR Checklist Trial.

Journal of general internal medicine·2026
Same author

Formation of task representations and replay in mouse medial prefrontal cortex.

eLife·2026
Same author

Complementary Bacterial Functions Enhance Mineralization of Aromatic Aliphatic Copolyesters within a Marine Microbial Consortium.

Environmental science & technology·2026
Same author

Challenges in perioperative code status management: a national survey among Swiss anaesthetists.

Resuscitation plus·2025
Same author

Challenges in laboratory diagnosis and antibiotic treatment options for a newly described Pseudomonas aeruginosa class A beta-lactamase type GES-62 strain.

GMS infectious diseases·2025
Same journal

Another 10 years of PLOS Computational Biology: A data-driven reflection on trends in genomics research.

PLoS computational biology·2026
Same journal

Mobility data resolution needed to inform predictive models of spatial epidemic spread from mobile phone data.

PLoS computational biology·2026
Same journal

DeepMethylation: A deep learning framework for tissue-specific DNA methylation prediction and functional variant annotation.

PLoS computational biology·2026
Same journal

Redefining and estimating the early-phase reproduction ratio for epidemic outbreaks in spatially structured populations.

PLoS computational biology·2026
Same journal

Optimized phenotype definitions boost GWAS power.

PLoS computational biology·2026
Same journal

Detection, communication, and individual identification with deep audio embeddings: A case study with North Atlantic right whales.

PLoS computational biology·2026
See all related articles

Related Experiment Video

Updated: Sep 18, 2025

Infant Auditory Processing and Event-related Brain Oscillations
06:34

Infant Auditory Processing and Event-related Brain Oscillations

Published on: July 1, 2015

16.5K

A mammalian inferior colliculus model for sound source separation using interaural time differences.

Christian Leibold1,2, Sebastian Groß3

  • 1Fakultät für Biologie & Bernstein Center Freiburg, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany.

Plos Computational Biology
|June 24, 2025
PubMed
Summary
This summary is machine-generated.

This study models the auditory midbrain, proposing that optimal cross-hemispheric delays in the inferior colliculus (IC) enhance sound source localization. ITD tuning in IC neurons may be a byproduct of this optimization.

More Related Videos

In Vitro Wedge Slice Preparation for Mimicking In Vivo Neuronal Circuit Connectivity
10:31

In Vitro Wedge Slice Preparation for Mimicking In Vivo Neuronal Circuit Connectivity

Published on: August 18, 2020

5.6K
Sound Source Localization Testing in Single-sided Deafness Following Bone Conduction Intervention
04:32

Sound Source Localization Testing in Single-sided Deafness Following Bone Conduction Intervention

Published on: December 20, 2024

440

Related Experiment Videos

Last Updated: Sep 18, 2025

Infant Auditory Processing and Event-related Brain Oscillations
06:34

Infant Auditory Processing and Event-related Brain Oscillations

Published on: July 1, 2015

16.5K
In Vitro Wedge Slice Preparation for Mimicking In Vivo Neuronal Circuit Connectivity
10:31

In Vitro Wedge Slice Preparation for Mimicking In Vivo Neuronal Circuit Connectivity

Published on: August 18, 2020

5.6K
Sound Source Localization Testing in Single-sided Deafness Following Bone Conduction Intervention
04:32

Sound Source Localization Testing in Single-sided Deafness Following Bone Conduction Intervention

Published on: December 20, 2024

440

Area of Science:

  • Neuroscience
  • Auditory System Modeling
  • Computational Neuroscience

Background:

  • The inferior colliculus (IC) is crucial for auditory processing, particularly interaural time differences (ITDs).
  • Mechanisms and functional roles of ITD tuning in the IC remain unclear, despite upstream generation in the superior olivary complex.
  • Fast synaptic kinetics in IC neurons necessitate precise temporal integration of inputs.

Purpose of the Study:

  • To investigate the role of cross-hemispheric delays from the lateral superior olive (LSO) to the IC.
  • To develop a normative model of midbrain auditory circuitry for optimizing ITD processing.
  • To understand how varying synaptic weights influence IC neuron function in complex auditory scenes.

Main Methods:

  • Developed a computational model of the midbrain auditory pathway.
  • Optimized cross-hemispheric delays and synaptic strengths by maximizing IC neuron firing rates for specific ITDs.
  • Focused on low-frequency sound processing.

Main Results:

  • Identified an optimal cross-hemispheric delay of 0.3 cycles for IC neurons.
  • Demonstrated that varying MSO and LSO input synaptic weights optimizes neurons for complex auditory scenes.
  • Model predictions align with experimental observations of best ITDs and near-optimal sound source reconstruction.

Conclusions:

  • Precise temporal integration of MSO and LSO inputs via optimized delays is critical for IC function.
  • ITD tuning in the IC may arise as a consequence of optimizing for broader auditory scene information.
  • The model provides insights into the neural basis of sound localization and auditory scene analysis.