Related Experiment Video
Updated: Sep 18, 2025
07:41
Modeling the Size Spectrum for Macroinvertebrates and Fishes in Stream Ecosystems
Published on: July 30, 2019
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There's Always a Bigger Fish
Nicolas Kitic1, Adélaïde Toutee1, Isabelle Audo2,3
1Department of Ophthalmology, Sorbonne University, Pitiè-Salpêtrière Hospital, Paris, France.
Ocular Immunology and Inflammation
|June 24, 2025
Summary
Cancer-associated retinopathy (CAR) can cause sudden vision loss and may precede cancer diagnosis. This case highlights a patient with tongue carcinoma who developed CAR due to a metastatic uterine neuroendocrine carcinoma.
Area of Science:
- Ophthalmology
- Oncology
- Neuroscience
Background:
- Cancer-associated retinopathy (CAR) is a rare paraneoplastic syndrome affecting the retina.
- It is often associated with various cancers, leading to progressive vision loss.
Observation:
- A 72-year-old female with tongue carcinoma presented with acute bilateral vision loss.
- Ophthalmological examination revealed rapid outer retinal atrophy.
- Systemic work-up unexpectedly identified metastatic uterine neuroendocrine carcinoma.
Findings:
- The patient experienced severe vision loss to light perception within days.
- Standard treatments including corticosteroids, plasmapheresis, and chemotherapy did not restore vision.
- CAR syndrome can manifest before the primary tumor is diagnosed.
Implications:
- This case underscores the importance of a comprehensive medical history and diagnostic work-up for CAR syndrome.
- Early identification of the underlying malignancy is crucial, even in patients with existing cancer diagnoses.
- CAR syndrome necessitates a broad oncological investigation to uncover the primary tumor source.
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