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Mechanistic insights into epigenetic contributions to psoriasis pathogenesis and their clinical implications
Yukun Wang1, Yuxiong Jiang1, Jiajing Lu1
1Department of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China; Institute of Psoriasis, Tongji University School of Medicine, Shanghai, China.
Abstract:
Psoriasis is a chronic inflammatory skin disease whose main manifestation is scaly and erythematous plaques. The pathogenesis is complex, including genetic and environmental factors. In recent years, epigenetic modifications, which means changing in gene expression instead of altering the DNA sequence, have been gradually studied by scholars as an important mechanism in psoriasis pathogenesis. The clinical application of epigenetics in psoriasis is promising with its potential as diagnostic biomarkers, predictors of disease progression, and targets for treatment. This review reveals the role of epigenetics in the pathogenesis of psoriasis and its contribution to clinical treatment for patients with psoriasis.
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