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Phase separation-based porous microneedle array for non-invasive point-of-care dermal interstitial fluid testing.

Xueqi Wang1, Kaidan Li2, Xianqiang Li2

  • 1School of Biomedical Engineering, Tsinghua University, Beijing, 100084, China.

Biosensors & Bioelectronics
|June 24, 2025
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Summary

A novel microneedle system offers non-invasive blood glucose monitoring using dermal interstitial fluid (DISF). This cost-effective, user-friendly approach provides accurate glucose prediction for diabetes management.

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Endocrinology

Background:

  • Diabetes mellitus requires consistent blood glucose monitoring for effective management and complication prevention.
  • Current monitoring methods, such as fingertip blood testing and continuous glucose monitoring, have limitations including invasiveness, cost, and complexity.
  • There is a need for user-friendly, non-invasive, and cost-effective blood glucose monitoring solutions for home use.

Purpose of the Study:

  • To develop and evaluate a phase separation-based porous microneedle analysis system for point-of-care dermal interstitial fluid (DISF) glucose testing.
  • To assess the accuracy and reliability of the proposed system for non-invasive blood glucose monitoring.
  • To demonstrate the system's capability for user-friendly, home-based blood glucose prediction.

Main Methods:

  • Development of a microneedle-based analysis system with separate sampling and detection modules.
  • Utilizing phase separation principles for glucose analysis in DISF.
  • Conducting in vitro assessments and on-body trials, including oral glucose tolerance tests (OGTT) and routine monitoring in healthy individuals and prediabetes patients.

Main Results:

  • The proposed microneedle system enables non-invasive, cost-effective, and user-friendly point-of-care DISF glucose testing.
  • On-body trials demonstrated consistent fluctuations between DISF and blood glucose concentrations during OGTT.
  • Routine tests showed excellent capability for blood glucose prediction in a non-invasive manner.

Conclusions:

  • The developed microneedle analysis system presents a promising solution for home-based, non-invasive blood glucose management.
  • This technology offers a user-friendly and rapid alternative to existing blood glucose monitoring methods.
  • The system has the potential to significantly improve the quality of life for individuals managing diabetes.