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Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy
Published on: May 26, 2023
Crocetin, a versatile carotenoid: Novel insights into pharmacological effects, molecular mechanisms, and therapeutic
Liping Liu1, Fan Qiu1, Dawei Wu1
1College of Traditional Chinese Medicine, Jiangsu Medical College, #283 Jiefang South Road, Yancheng 224000, Jiangsu, China.
Abstract:
Plant-derived natural products have emerged as indispensable resources in modern drug discovery, and demonstrated remarkable potential across diverse disease domains. As a representative bioactive carotenoid, crocetin features a unique polyunsaturated oleic acid structure, extracted from the stigma of Crocus sativus L. Recent studies have revealed that crocetin has multiple pharmacological effects and biological activities, including anti-tumor, hepatoprotective, analgesic, neuroprotective, cardioprotective, anti-radiation and other protective effects. The present comprehensive review synthesizes cutting-edge advances in crocetin research, systematically evaluating its multifaceted pharmacological actions, pharmacokinetic profiles and dose-dependent toxicity thresholds. Particularly noteworthy is our mechanistic elucidation of crocetin's disease-modulating capabilities, which offers promising research prospects for the development and utilization of the medicinal value of crocetin.
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