Related Experiment Video

Updated: Sep 18, 2025

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining
07:32

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

473

Different patterns of brain iron deposition exist in peritoneal dialysis and hemodialysis patients with cognitive

Jiamin Liu1, Wenbo Yang2, Lijun Song2

  • 1Department of Nephrology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Renal Failure
|June 24, 2025
PubMed

Insights

Cognitive impairment is rising in dialysis patients. This study found abnormal brain iron deposition in peritoneal dialysis (PD) patients, which may link to cognitive decline.

Area of Science:

  • Nephrology
  • Neuroimaging
  • Cognitive Science

Background:

  • Cognitive impairment is increasingly observed in patients undergoing peritoneal dialysis (PD) and hemodialysis (HD).
  • The underlying mechanisms, particularly concerning brain iron homeostasis, remain unclear.
  • Iron disruption is a known factor associated with cognitive decline.

Purpose of the Study:

  • To investigate the relationship between brain iron deposition and cognitive function in PD and HD patients.
  • To utilize quantitative susceptibility mapping (QSM) for assessing brain iron content.
  • To compare iron deposition patterns between PD patients, HD patients, and healthy controls.

Main Methods:

  • A cross-sectional study included 56 PD patients, 66 HD patients, and 56 healthy controls (HC).
  • Quantitative Susceptibility Mapping (QSM) measured brain iron levels, and the Montreal Cognitive Assessment (MoCA) evaluated cognitive function.
  • Statistical analyses included ANOVA for group comparisons and Pearson correlation for assessing relationships between iron levels, clinical data, and MoCA scores.

Main Results:

  • PD patients exhibited higher brain iron susceptibility values in the bilateral caudate nuclei (CAU) and left thalamus (THA) compared to HC.
  • PD patients showed increased susceptibility values in the left thalamus compared to HD patients.
  • A negative correlation was observed between brain iron susceptibility values and MoCA scores in PD patients.

Conclusions:

  • Distinct patterns of brain iron deposition exist between PD and HD patients.
  • Abnormal brain iron accumulation in PD patients is potentially linked to their cognitive impairment.
Abstract

Keywords:
Brain iron depositioncognitive impairmenthemodialysisperitoneal dialysisquantitative susceptibility mapping

More Related Videos

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis04:36

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis

Published on: October 2, 2020

2.3K
Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

14.2K

Related Concept Videos

Peritoneal Dialysis III: Nursing Management01:25

Peritoneal Dialysis III: Nursing Management

Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
159
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
107
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
146