Novel enabling strategies for oral peptide delivery

Area of Science:

• Pharmaceutical Sciences
• Biotechnology
• Drug Delivery Systems

Background:

• The oral peptide delivery market is expanding rapidly due to rising chronic diseases.
• Current oral peptide delivery faces significant hurdles including enzymatic degradation, poor stability, limited permeability, and low bioavailability.
• Overcoming these challenges is crucial for developing effective oral peptide therapeutics.

Purpose of the Study:

• To review the challenges inherent in oral peptide delivery.
• To offer new perspectives on strategies for successful oral peptide therapeutics.
• To highlight innovative approaches like 3D printing, hydrophobic ion pairing, and SNEDDS.

Main Methods:

• Literature review focusing on challenges and advancements in oral peptide delivery.
• Analysis of emerging technologies and formulation strategies.
• Synthesis of information on 3D printing, hydrophobic ion pairing, and SNEDDS.

Main Results:

• Identified key barriers to oral peptide absorption in the gastrointestinal tract.
• Evaluated the potential of 3D printing for controlled peptide release.
• Assessed the efficacy of hydrophobic ion pairing and SNEDDS in enhancing peptide stability and permeability.

Conclusions:

• Despite significant challenges, advancements in drug delivery are paving the way for oral peptide therapeutics.
• 3D printing, hydrophobic ion pairing, and SNEDDS represent promising strategies to overcome current limitations.
• Further research and development in these areas could revolutionize peptide-based treatments.