Prevalence of depression and anxiety in gestational trophoblastic disease: A systematic review and meta-analysis

ObjectiveThe objective of this systematic review and meta-analysis is to determine the prevalence of anxiety and depression among individuals diagnosed with gestational trophoblastic disease (GTD), considering the significant emotional toll associated with miscarriage, surgical procedures, and prolonged β-hCG monitoring.MethodsWe systematically searched for studies published up to February 2024 that reported on the prevalence of anxiety and depression in GTD. The databases included PubMed, ScienceDirect, Cochrane Library, EBSCOHost, ProQuest, and Google Scholar. Data from the included studies were independently extracted by four researchers and analyzed using MedCalc v19.5.1. This study was registered with PROSPERO (registration number CRD42024525746).ResultsOur analysis included seven studies involving a total of 462 participants. The findings revealed an overall prevalence of anxiety at 34.9% and depression at 22.2%, indicating a significant psychological impact on patients with GTD.ConclusionThe high prevalence of anxiety and depression underscores the necessity for physicians to provide comprehensive psychological support to patients with GTD. Educating patients about their disorder, treatment options, and potential consequences is crucial for managing the psychological aspects of GTD.