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Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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Positron Emission Tomography01:29

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
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Related Experiment Video

Updated: Sep 18, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Diagnosing Organ Involvement in Juvenile Systemic Sclerosis with 68Ga-FAPI-46 PET/CT.

Tobias Krickau1,2, Joachim Woelfle3,2, Michael Beck4

  • 1Department of Paediatrics and Adolescent Medicine, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; tobias.krickau@uk-erlangen.de.

Journal of Nuclear Medicine Technology
|June 24, 2025
PubMed
Summary
This summary is machine-generated.

Gallium-68 fibroblast activation protein inhibitor (FAPI)-46 PET/CT effectively identifies organ involvement in juvenile systemic sclerosis (jSSc). This imaging technique reveals inflammation and fibrosis, offering valuable insights into disease activity.

Keywords:
68Ga-FAPI-46 PET/CTautoantibody profilejuvenile systemic sclerosis

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Area of Science:

  • Nuclear Medicine
  • Radiology
  • Rheumatology

Background:

  • Juvenile systemic sclerosis (jSSc) is a complex autoimmune disease characterized by inflammation and fibrosis.
  • Accurate assessment of organ involvement is crucial for managing jSSc and predicting prognosis.
  • Current diagnostic methods may not fully capture the extent of subclinical disease activity.

Purpose of the Study:

  • To evaluate the diagnostic utility of 68Ga-fibroblast activation protein inhibitor (FAPI)-46 Positron Emission Tomography/Computed Tomography (PET/CT).
  • To assess the capability of 68Ga-FAPI-46 PET/CT in detecting organ involvement in patients with jSSc.
  • To explore the potential of 68Ga-FAPI-46 PET/CT in identifying inflammation and fibrosis in jSSc.

Main Methods:

  • Retrospective analysis of 4 pediatric patients diagnosed with jSSc.
  • All patients underwent 68Ga-FAPI-46 PET/CT imaging.
  • Imaging timing varied: 3 patients before immunomodulatory drugs, 1 patient after active disease progression.

Main Results:

  • 68Ga-FAPI-46 PET/CT successfully identified all known organ manifestations of jSSc in the case series.
  • The imaging modality revealed previously unrecognized cardiac and muscular involvement.
  • The technique demonstrated potential in visualizing fibrotic processes associated with jSSc.

Conclusions:

  • 68Ga-FAPI-46 PET/CT is a valuable tool for assessing disease activity in jSSc.
  • This imaging approach enhances the detection of organ involvement, including previously undetected sites.
  • Further research with 68Ga-FAPI-46 PET/CT in jSSc patients is warranted to confirm these findings.