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New method of respiratory gas analysis: light spectrometer
Journal of Applied Physiology (Bethesda, Md. : 1985)
|September 1, 1985
Summary
A novel glow discharge spectral emission gas analyzer (GDSEA) offers rapid, accurate respiratory gas analysis for O2, N2, CO2, He, and N2O. Clinical evaluations show close agreement with mass spectrometry for gas concentrations and derived respiratory variables.
Area of Science:
- Medical Devices
- Analytical Chemistry
- Respiratory Physiology
Background:
- Accurate respiratory gas analysis is crucial for patient monitoring.
- Existing methods may have limitations in speed or sample requirements.
Purpose of the Study:
- To develop and evaluate a new gas analyzer for respiratory applications.
- To assess the performance of the glow discharge spectral emission gas analyzer (GDSEA) against established technology.
Main Methods:
- Development of a GDSEA utilizing direct current glow discharge.
- Simultaneous measurement of multiple respiratory gases (O2, N2, CO2, He, N2O).
- Laboratory and clinical evaluations comparing GDSEA with mass spectrometry.
Main Results:
- GDSEA demonstrated rapid response times (100 ms) and low sample rates (<20 ml/min).
- Laboratory accuracy was +/- 0.15% to +/- 0.7% with resolution of 0.02-0.05%.
- Clinical comparison showed <2% difference in O2/CO2 and <5% difference in derived respiratory variables compared to mass spectrometry.
Conclusions:
- The GDSEA is a viable tool for simultaneous respiratory gas analysis.
- The instrument provides accurate and rapid measurements suitable for clinical settings.
- GDSEA performance closely correlates with mass spectrometry, offering a promising alternative.