Related Experiment Video
Updated: Sep 18, 2025
03:24
Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging
Published on: March 22, 2024
1.7K
Pathogenicity Evaluation on Fluconazole-Resistant Candida auris Clade V in Murine Model
Robab Ebrahimi Barough1,2,3, Hamid Badali4, Fereshteh Talebpour Amiri5
1Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
Mycopathologia
|June 24, 2025
Summary
Candida auris clade V shows significant pathogenicity in mice, but amphotericin B treatment improves survival rates. This highlights the need for effective antifungal therapies against this emerging multidrug-resistant fungus.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Candida auris is a multidrug-resistant fungus causing global health concerns.
- Clade V of C. auris has limited available pathogenicity data.
- C. auris infections are reported globally across multiple clades.
Purpose of the Study:
- To evaluate the pathogenicity of fluconazole-resistant C. auris clade V.
- To assess the therapeutic efficacy of amphotericin B against C. auris clade V.
- To compare C. auris clade V pathogenicity with Candida albicans in an immunocompromised mouse model.
Main Methods:
- Infection of immunocompromised mice with C. auris clade V and C. albicans.
- Monitoring of mortality rates, fungal burden in tissues, and histopathological changes.
- Administration of amphotericin B to assess therapeutic efficacy.
Main Results:
- C. auris clade V exhibited higher fungal loads in heart and kidney tissues compared to C. albicans.
- C. albicans showed higher fungal loads in spleen and heart at specific time points.
- Amphotericin B treatment significantly improved the survival rate of mice infected with C. auris clade V.
Conclusions:
- C. auris clade V demonstrates significant pathogenic potential, posing a threat even at lower levels.
- Despite C. albicans showing greater virulence in untreated infections, C. auris clade V is a serious concern.
- Amphotericin B is an effective therapeutic intervention for C. auris clade V infections, underscoring the need for optimized treatment strategies.
