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Cultivation of Mammalian Cells Using a Single-use Pneumatic Bioreactor System
Published on: October 10, 2014
Bacterial population dynamics and biosafety assessment in a closed Bioregenerative Life Support System during the
Yuming Fu1,2,3, Yueying Lu4,5,6, Jianlou Yang4,5,6,7
1Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology, National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China. fuyuming@buaa.edu.cn.
Abstract:
Our study investigates the dynamic variation of bacterial populations within the Bioregenerative Life Support System (BLSS), a critical component for sustainable habitats in extraterrestrial environments supporting human survival. We utilized the ground-based BLSS test platform, referred to as "Lunar Palace 1" (LP1), to examine bacterial dynamics in an ecosystem integrating plant production, human cultivation, and equipment maintenance. Our findings reveal distinct bacterial compositions among crew members and functional areas within the LP1 system while preserving temporal stability across the 370-day experiment. Importantly, we observed a low abundance of potential pathogens, minimal antibiotic resistance, and negligible impact of the isolated bacterial strains on equipment materials, suggesting favorable biosafety attributed to plant integration. Our work enhances the understanding of microbial communities in BLSS and underscores the importance of incorporating green plants to bolster environmental biosafety and sustainability in long-term space exploration missions.
