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Long-Term Survivor of Laryngeal Small Cell Neuroendocrine Carcinoma

  • 0Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
The Permanente Journal +

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June 25, 2025

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June 25, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

This case study shows a 5-year survival for advanced laryngeal small cell neuroendocrine carcinoma (SCNC) using chemotherapy and radiation. Aggressive multimodal treatment may improve outcomes for this rare cancer.

Area Of Science

  • Oncology
  • Otolaryngology
  • Pathology

Background

  • Small cell neuroendocrine carcinoma (SCNC) of the larynx is a rare and aggressive malignancy.
  • Limited data exists on effective treatment strategies and prognosis for laryngeal SCNC.
  • Advanced stage disease typically carries a poor prognosis.

Purpose Of The Study

  • To report a case of long-term survival in advanced laryngeal SCNC.
  • To highlight the potential benefits of aggressive multimodal treatment for laryngeal SCNC.
  • To stimulate discussion on surgical roles and individualized survivorship care.

Main Methods

  • A case report of a 51-year-old male with stage IVa laryngeal SCNC.
  • Treatment involved platinum-based chemotherapy and radiation therapy.
  • Disease-free survival was monitored for over 5 years.

Main Results

  • The patient achieved over 5 years of disease-free survival.
  • This represents one of few reported instances of extended survival for laryngeal SCNC.
  • The case demonstrates the potential efficacy of multimodal therapy in advanced stages.

Conclusions

  • Aggressive multimodal treatment, including chemotherapy and radiation, may offer long-term survival for advanced laryngeal SCNC.
  • Further research is needed to establish standardized treatment and surveillance strategies.
  • Individualized care and consideration of surgery in select cases are important for survivorship.

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