Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

MAD-MT Score: A Tool to Optimize Patient Selection for Mechanical Thrombectomy in Distal Vessel Occlusions.

Stroke·2026

Same author

Real-World Safety Profile of Middle Meningeal Artery Embolization for Chronic Subdural Hematoma: a Multinational Multicenter Study.

Clinical neuroradiology·2026

Same author

Antithrombotic therapy and risk of intracranial hemorrhage in patients with cerebral cavernous malformations: a multicenter propensity-matched cohort study.

Journal of neurology·2026

Same author

Treatment of Middle Cerebral Artery Aneurysms with Flow-Diverter Stents: A Systematic Review and Meta-Analysis of 1036 Aneurysms.

AJNR. American journal of neuroradiology·2026

Same author

Temporal relationship between hematoma resolution and functional recovery after middle meningeal artery embolization for chronic subdural hematoma.

Journal of neurosurgery·2026

Same author

International multi-center study to quantify the effect of deep venous drainage after surgical resection of Spetzler-Martin Grade II-III brain arteriovenous malformations.

Neurosurgical review·2026

Search research articles

Related Experiment Video

Updated: May 6, 2026

A Large Lateral Craniotomy Procedure for Mesoscale Wide-field Optical Imaging of Brain Activity

A Large Lateral Craniotomy Procedure for Mesoscale Wide-field Optical Imaging of Brain Activity

Published on: May 7, 2017

Bone Graft Expansion in Cranioplasty Using a Split-Bone Technique.

Norris C Talbot¹, Carlie Proctor², Patrick Luther³

¹School of Medicine, Louisiana State University Health Sciences Center, Shreveport, USA.

|June 25, 2025

Summary

This summary is machine-generated.

A novel bone flap splitting technique for cranioplasty effectively manages persistent brain edema after decompressive hemicraniectomy (DHC). This method avoids invasive drain placement, ensuring patient safety and successful outcomes in DHC patients.

Keywords:

cerebral edema craniectomy cranioplasty craniotomy neurocritical care

More Related Videos

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Published on: December 22, 2015

Rapid Isolation of BMPR-IB+ Adipose-Derived Stromal Cells for Use in a Calvarial Defect Healing Model

Rapid Isolation of BMPR-IB+ Adipose-Derived Stromal Cells for Use in a Calvarial Defect Healing Model

Published on: February 24, 2017

Related Experiment Videos

Last Updated: May 6, 2026

A Large Lateral Craniotomy Procedure for Mesoscale Wide-field Optical Imaging of Brain Activity

A Large Lateral Craniotomy Procedure for Mesoscale Wide-field Optical Imaging of Brain Activity

Published on: May 7, 2017

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Published on: December 22, 2015

Rapid Isolation of BMPR-IB+ Adipose-Derived Stromal Cells for Use in a Calvarial Defect Healing Model

Rapid Isolation of BMPR-IB+ Adipose-Derived Stromal Cells for Use in a Calvarial Defect Healing Model

Published on: February 24, 2017

Area of Science:

Neurosurgery
Surgical Innovation

Background:

Decompressive hemicraniectomy (DHC) treats uncontrollable intracranial hypertension.
Cranioplasty, the bone flap replacement, typically occurs 3-6 months post-injury.
Persistent cerebral edema during cranioplasty poses surgical challenges.

Observation:

Standard cranioplasty may require intraoperative interventions like mannitol or drain placement for persistent cerebral edema.
These interventions carry risks and can delay the procedure.
A novel technique involving splitting the bone flap was developed to address these challenges.

Findings:

The study successfully implemented a bone flap splitting technique in three patients with persistent cerebral edema post-DHC.
This technique increased bone flap size and flexibility, accommodating brain swelling.
All patients tolerated the procedure well, with no postoperative complications or new cranial defects.

Implications:

This bone flap modification offers a viable alternative to invasive drain placement during cranioplasty for persistent cerebral edema.
It potentially reduces surgical risks and procedure delays.
The technique demonstrates a promising approach to managing complex cranioplasty cases following DHC.