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Systemic Lupus Erythematosus and Psoriasis Overlap: A Case Series
Mohannad Ali1, Saud Abdullah1, Yasameen Abdulhameed1
1Internal Medicine, DubaiHealth, Dubai, ARE.
Cureus
|June 25, 2025
Summary
Systemic lupus erythematosus (SLE) and psoriasis can coexist, presenting diagnostic and management challenges. Biological therapies showed promise for managing psoriasis without triggering SLE flares in a case series.
Area of Science:
- Rheumatology
- Immunodermatology
Background:
- Systemic lupus erythematosus (SLE) is a complex autoimmune disease with varied presentations.
- Overlap syndromes are common in SLE, but SLE coexisting with psoriasis is rare and under-reported.
- Distinct immunopathological mechanisms underlie SLE and psoriasis.
Observation:
- A case series of four female patients with both SLE and psoriasis was analyzed.
- Patients experienced complex, relapsing-remitting disease courses.
- Challenges included diagnosis, overlapping symptoms (cutaneous and joint), and treatment.
Findings:
- Expert medical opinion and biochemical evidence confirmed SLE and psoriasis diagnoses.
- Biological therapy was effective in achieving psoriasis remission.
- Importantly, biological therapy did not precipitate SLE flares in these patients.
Implications:
- This case series highlights the potential for effective management of coexisting SLE and psoriasis.
- Biological therapies may offer a safe and effective treatment option for patients with both conditions.
- Further research is warranted to explore optimal therapeutic strategies for this rare overlap syndrome.
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