Presumed Solitary Circumscribed Retinal Astrocytic Proliferation: A Case Report
Mojtaba Abrishami1,2, Daniel J Weisbrod1,3, Hatem Krema1
1Department of Ophthalmology and Vision Sciences, Princess Margaret Cancer Center/University Health Network, University of Toronto, Toronto, ON, Canada.
Journal of Current Ophthalmology
|June 25, 2025
Summary
This case report details a rare retinal tumor, solitary circumscribed retinal astrocytic proliferation (PSCRAP), diagnosed using advanced imaging. The findings highlight the importance of multimodal imaging for identifying unique features of this benign condition.
Area of Science:
- Ophthalmology
- Medical Imaging
- Retinal Diseases
Background:
- Solitary circumscribed retinal astrocytic proliferation (PSCRAP) is a rare, benign retinal tumor.
- Accurate diagnosis is crucial for differentiating PSCRAP from other retinal pathologies.
Observation:
- A 41-year-old female presented with asymptomatic, stable, whitish retinal lesions.
- Multimodal imaging, including spectral-domain optical coherence tomography (SD-OCT) and optical coherence tomography angiography (OCTA), revealed unique characteristics of the lesions.
- The lesions appeared as hyperreflective intraretinal masses with optical shadowing and lacked intrinsic vascularity.
Findings:
- SD-OCT showed hyperreflective intraretinal masses with optical shadowing and separation from the retinal nerve fiber layer.
- OCTA demonstrated a signal void in the retinal vascular plexuses, indicating lack of vascularity.
- Fundus autofluorescence showed moderate hyperautofluorescence.
Implications:
- Multimodal imaging is essential for the diagnosis of PSCRAP, revealing characteristic features.
- The presence of two lesions challenges the 'solitary' nature of this condition, suggesting further documentation may be needed.
- Continued monitoring is important to distinguish PSCRAP from potentially growing simulating lesions.
